Médecine interne


Médecine interne


Publications recentes

A nationwide study of acquired C1-inhibitor deficiency in France: Characteristics and treatment responses in 92 patients. Gobert D, Paule R, Ponard D, Levy P, Frémeaux-Bacchi V, Bouillet L, Boccon-Gibod I, Drouet C, Gayet S, Launay D, Martin L, Mekinian A, Leblond V, Fain O. Medicine (Baltimore). 2016 Aug;95(33):e4363

Risk factors associated with intracranial hemorrhage in adults with immune thrombocytopenia: A study of 27 cases. Melboucy-Belkhir S, Khellaf M, Augier A, Boubaya M, Levy V, Le Guenno G, Terriou L, Lioger B, Ebbo M, Morin AS, Chauveheid MP, Michel M, Belkhir F, About F, Rose C, Moulis G, Mekinian A, Stirnemann J, Papo T, Cheze S, Rosenthal E, Viallard JF, Schleinitz N, Galicier L, Adoue D, Lambotte O, Hamidou M, Godeau B, Fain O. Am J Hematol. 2016 Aug 16

Digestive-tract sarcoidosis: French nationwide case-control study of 25 cases. Ghrenassia E, Mekinian A, Chapelon-Albric C, Levy P, Cosnes J, Sève P, Lefèvre G, Dhôte R, Launay D, Prendki V, Morell-Dubois S, Sadoun D, Mehdaoui A, Soussan M, Bourrier A, Ricard L, Benamouzig R, Valeyre D, Fain O; Groupe Sarcoïdose Francophone. Medicine (Baltimore). 2016 Jul;95(29):e4279

Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort. Alijotas-Reig J, Ferrer-Oliveras R, Esteve-Valverde E, Ruffatti A, Tincani A, Lefkou E, Bertero MT, Espinosa G, Coloma E, de Carolis S, Rovere-Querini P, Canti V, Picardo E, Fredi M, Mekinian A; EUROAPS Study Group. Am J Reprod Immunol. 2016 Aug;76(2):164-71

Autoimmune and inflammatory diseases associated with chronic myelomonocytic leukemia: A series of 26 cases and literature review. Grignano E, Mekinian A, Braun T, Liozon E, Hamidou M, Decaux O, Puéchal X, Kahn JE, Schoindre Y, Rossignol J, Lortholary O, Lioger B, Hermine O, Park S, Ades L, Montestruc F, Ricard L, Gardin C, Fenaux P, Fain O; GFM, SNFMI and CRI. Leuk Res. 2016 Aug;47:136-41.

Positron emission tomography and computed tomography angiography for the diagnosis of giant cell arteritis: A real-life prospective study. Lariviere D, Benali K, Coustet B, Pasi N, Hyafil F, Klein I, Chauchard M, Alexandra JF, Goulenok T, Dossier A, Dieude P, Papo T, Sacre K. Medicine (Baltimore). 2016 Jul;95(30):e4146.

Efficacy of Azacitidine in autoimmune and inflammatory disorders associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Fraison JB, Mekinian A, Grignano E, Kahn JE, Arlet JB, Decaux O, Denis G, Buchdahl AL, Omouri M, Maigne G, Aouba A, Leon N, Berthier S, Liozon E, Park S, Gardin C, Lortholary O, Rossignol J, Fenaux P, Fain O, Braun T. Leuk Res. 2016 Apr;43:13-7

Hereditary angioedema with F12 mutation: first report of three cases associated with immune disorders. Irène GS, Dhôte R, Caux F, Mèkinian A, Fain O. Clin Med (Lond). 2016 Apr;16(2):206

[Usefulness of imaging in large vessel vasculitis]. Mekinian A, Djelbani S, Viry F, Fain O, Soussan M. Rev Med Interne. 2016 Apr;37(4):245-55.

Unexplained Recurrent Miscarriage and Recurrent Implantation Failure: Is There a Place for Immunomodulation? Mekinian A, Cohen J, Alijotas-Reig J, Carbillon L, Nicaise-Roland P, Kayem G, Daraï E, Fain O, Bornes M. Am J Reprod Immunol. 2016 Jul;76(1):8-28

Predictors of Pregnancy Outcomes in Patients With Lupus. Carbillon L, Benbara A, Boujenah J, de la Hosseraye C, Mekinian A. Ann Intern Med. 2016 Jan 19;164(2):131

Kawasaki disease in adults: Observations in France and literature review. Fraison JB, Sève P, Dauphin C, Mahr A, Gomard-Mennesson E, Varron L, Pugnet G, Landron C, Roblot P, Oziol E, Chalhoub G, Galempoix JM, Humbert S, Humbert P, Sbidian E, Grange F, Bayrou O, Cathebras P, Morlat P, Epaulard O, Pavese P, Huong du LT, Zoulim A, Stankovic K, Bachelez H, Smail A, Bachmeyer C, Granel B, Serratrice J, Brinchault G, Mekinian A, Costedoat-Chalumeau N, Bourgarit-Durand A, Puéchal X, Guillevin L, Piram M, Koné-Paut I, Fain O; CRI and the French Vasculitis Study Group. Autoimmun Rev. 2016 Mar;15(3):242-9

Bradykinin-mediated angioedema: factors associated with admission to an intensive care unit, a multicenter study. Javaud N, Floccard B, Gontier F, Lapostolle F, Boccon-Gibod I, Martin L, Amarger S, Boumedienne A, Boubaya M, Asfar P, Coppere B, Ollivier Y, Bouillet L, Adnet F, Fain O. Eur J Emerg Med. 2015, Feb 24.

Treatment of Systemic Necrotizing Vasculitides in Patients over 65 Years. Pagnoux C, Quéméneur T, Ninet J, Diot E, Kyndt X, de Wazières B, Reny JL, Puéchal X, Leberruyer PY, Lidove O, Vanhille P, Godmer P, Fain O, Blockmans D, Bienvenu B, Rollot F, Poignant S, Mahr A, Cohen P, Mouthon L, Perrodeau E, Ravaud P, Guillevin L; for the French Vasculitis Study Group (FVSG).  Arthritis Rheumatol. 2015 Feb 18.

Hereditary angioedema and lupus: A French retrospective study and literature review. Gallais Sérézal I, Bouillet L, Dhôte R, Gayet S, Jeandel PY, Blanchard-Delaunay C, Martin L, Mekinian A, Fain O. Autoimmun Rev. 2015, Feb 4.

The efficacy of hydroxychloroquine for obstetrical outcome in anti-phospholipid syndrome: Data from a European multicenter retrospective study. Mekinian A, Lazzaroni MG, Kuzenko A, Alijotas-Reig J, Ruffatti A, Levy P, Canti V, Bremme K, Bezanahary H, Bertero T, Dhote R, Maurier F, Andreoli L, Benbara A, Tigazin A, Carbillon L, Nicaise-Roland P, Tincani A, Fain O; on the behalf of the SNFMI and the European Forum on Antiphospholipid Antibodies. Autoimmun Rev. 2015 Jan 21.

AA amyloidosis treated with tocilizumab: case series and updated literature review. Courties A, Grateau G, Philippe P, Flipo RM, Astudillo L, Aubry-Rozier B, Fabreguet I, Fahd W, Fain O, Guggenbuhl P, Hachulla E, Papo T, Richez C, Sibilia J, Morel J, Berenbaum F, Sellam J; on behalf of the Club Rhumatismes Inflammation and the REGATE Registry. Amyloid. 2015 Jan 14:1-9

Acquired angioedema. Fain O, Gobert D, Khau CA, Mekinian A, Javaud N. Presse Med. 2015 Jan;44(1):48-51.

Drug induced angioedema (ACE-inhibitors and other). Fain O, Mekinian A, Gobert D, Khau CA, Javaud N. Presse Med. 2015 Jan;44(1):43-7.

Kikuchi-Fujimoto disease: retrospective study of 91 cases and review of the literature. Dumas G, Prendki V, Haroche J, Amoura Z, Cacoub P, Galicier L, Meyer O, Rapp C, Deligny C, Godeau B, Aslangul E, Lambotte O, Papo T, Pouchot J, Hamidou M, Bachmeyer C, Hachulla E, Carmoi T, Dhote R, Gerin M, Mekinian A, Stirnemann J, Charlotte F, Farge D, Molina T, Fain O. Medicine (Baltimore). 2014 Nov;93(24):372-82.

Inefficacy of plasma exchanges associated to rituximab in refractory obstetrical antiphospholipid syndrome. Abisror N, Mekinian A, Brechignac S, Ruffatti A, Carbillon L, Fain O. Presse Med. 2015 Jan;44(1):100-2.

Antiphospholipid syndrome and other autoimmune diseases associated with chronic intervillositis. Revaux A, Mekinian A, Nicaise P, Bucourt M, Cornelis F, Lachassinne E, Chollet-Martin S, Fain O, Carbillon L. Arch Gynecol Obstet. 2014 Nov 22.

Lower vitamin D levels are associated with higher systemic lupus erythematosus activity, but not predictive of disease flare-up. Schoindre Y, Jallouli M, Tanguy ML, Ghillani P, Galicier L, Aumaître O, Francès C, Le Guern V, Lioté F, Smail A, Limal N, Perard L, Desmurs-Clavel H, Le Thi Huong D, Asli B, Kahn JE, Sailler L, Ackermann F, Papo T, Sacré K, Fain O, Stirnemann J, Cacoub P, Leroux G, Cohen-Bittan J, Hulot JS, Lechat P, Musset L, Piette JC, Amoura Z, Souberbielle JC, Costedoat-Chalumeau N; Group PLUS. Lupus Sci Med. 2014 Jun 7;1(1)

Mutation V111I in HIV-2 reverse transcriptase increases the fitness of the nucleoside analogue-resistant K65R and Q151M viruses. Deuzing IP, Charpentier C, Wright DW, Matheron S, Paton J, Frentz D, van de Vijver DA, Coveney PV, Descamps D; ANRS CO5 HIV-2 Cohort, Boucher CA, Beerens N. J Virol. 2015 Jan;89(1):833-43.

Progestins are efficient agents in estrogen-sensitive nonhistaminic angioedema. Gompel A, Fain O, Bouillet L. Am J Med. 2014 Oct;127(10)

Safety and efficacy of rituximab in adult immune thrombocytopenia: results from a prospective registry including 248 patients. Khellaf M, Charles-Nelson A, Fain O, Terriou L, Viallard JF, Cheze S, Graveleau J, Slama B, Audia S, Ebbo M, Le Guenno G, Cliquennois M, Salles G, Bonmati C, Teillet F, Galicier L, Hot A, Lambotte O, Lefrère F, Sacko S, Kengue DK, Bierling P, Roudot-Thoraval F, Michel M, Godeau B. Blood. 2014 Nov 20;124(22):3228-36.

Profound symptomatic hypogammaglobulinemia: a rare late complication after rituximab treatment for immune thrombocytopenia. Report of 3 cases and systematic review of the literature. Levy R, Mahévas M, Galicier L, Boutboul D, Moroch J, Loustau V, Guillaud C, Languille L, Fain O, Bierling P, Khellaf M, Michel M, Oksenhendler E, Godeau B. Autoimmun Rev. 2014 Oct;13(10):1055-63.

Obstetrical APS: is there a place for hydroxychloroquine to improve the pregnancy outcome? Mekinian A, Costedoat-Chalumeau N, Masseau A, Tincani A, De Caroli S, Alijotas-Reig J, Ruffatti A, Ambrozic A, Botta A, Le Guern V, Fritsch-Stork R, Nicaise-Roland P, Carbonne B, Carbillon L, Fain O. Autoimmun Rev. 2015 Jan;14(1):23-9.

Hereditary angioedema with F12 mutation: factors modifying the clinical phenotype. Charignon D, Ghannam A, Defendi F, Ponard D, Monnier N, López Trascasa M, Launay D, Caballero T, Djenouhat K, Fain O, Cichon S, Martin L, Drouet C. Allergy. 2014 Dec;69(12):1659-65.

Obstetrical APS: Is there a place for hydroxychloroquine to improve the pregnancy outcome ? Mekinian A, Costedoat-Chalumeau N, Masseau A, Tincani A, De Caroli S, Jaume AR, Ruffatti A, Ambrozic A, Botta A, Le Guern V, Fritsch-Stork R, Nicaise-Roland P, Carbonne B, Carbillon L, Fain O.  Autoimmun Rev. 2014 Aug 30. Epub

Autoimmune diseases in HIV-infected patients: 52 cases and literature review. Iordache L, Launay O, Bouchaud O, Jeantils V, Goujard C, Boue F, Cacoub P, Hanslik T, Mahr A, Lambotte O, Fain O; Associated authors. Autoimmun Rev. 2014 Aug;13(8):850-7.

Chronic histiocytic intervillositis: Outcome, associated diseases and treatment in a multicenter prospective study. Mekinian A, Costedoat-Chalumeau N, Masseau A, Botta A, Chudzinski A, Theulin A, Emmanuelli V, Hachulla E, De Carolis S, Revaux A, Nicaise P, Cornelis F, Subtil D, Montestruc F, Bucourt M, Chollet-Martin S, Carbillon L, Fain O; on the behalf of the SNFMI and the European Forum of APS. Autoimmunity. 2014 Jul 16:1-6. [Epub ahead of print]

Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicentre retrospective study. Ruffatti A, Salvan E, Del Ross T, Gerosa M, Andreoli L, Maina A, Alijotas-Reig J, De Carolis S, Mekinian A, Bertero MT, Canti V, Brucato A, Bremme K, Ramoni V, Mosca M, Di Poi E, Caramaschi P, Galeazzi M, Tincani A, Meroni PL. Thromb Haemost. 2014 Jul 10;112(4).

Mothers’ antiphospholipid antibodies during pregnancy and the relation to offspring outcome. Mekinian A, Carbillon L, Nicaise-Roland P, Rousseau H, Lachassinne E, Motta M, Vicaut E, Boinot C, Avcin T, De Carolis S, Rovere-Querini P, Lambert M, Derenne S, Pourrat O, Chollet-Martin S, Biasini-Rebaioli R, Rovelli R, Lojacono A, Ambrozic A, Benbara A, Pierre F, Allegri F, Nuzzo M, Hatron PY, Tincani A, Aurousseau MH, Boffa MC, Fain O. Clin Exp Rheumatol. 2014 May-Jun;32(3):446.

Efficacy of imatinib mesylate in a case of Churg-Strauss syndrome: evidence for the pathogenic role of a tyrosine kinase? Josselin-Mahr L, Werbrouck-Chiraux A, Garderet L, Cabane J. Rheumatology (Oxford). 2014 Feb;53(2):378-9

Systemic vasculitis Fain O, Mekinian A. Rev Prat. 2014;64(1):113-26.

Idiopathic retroperitoneal fibrosis: A multicentric retrospective study of 30 French cases and follow-up of the renal function. Gallais Sérézal I, Le Jeune S, Belenfant X, Bakir R, Fain O, Mekinian A, Gambier N, Mouthon L, Steichen O, Blanche P, Mourad JJ, Dhôte R.  Rev Med Interne. 2013 (in press)

Inflammatory arthritis in patients with myelodysplastic syndrome: A French multicenter retrospective study. Mekinian A, Thorsten Braun, Olivier Decaux, Géraldine Falgarone, Eric Toussirot, Loic Raffray, Mohamed Omouri, Bruno Gombert, Benoit De Wazieres, Anne-Laure Buchdaul, Jean-Marc Ziza, David Launay, Guillaume Denis, Serge Madaule, Christian Rose, Eric Grignano, Pierre Fenaux, Olivier Fain, on the behalf of the Club Rhumatismes et Inflammation, GFM and SNFMI. Medicine 2014;93(1):1-10.

FDG-PET/CT in patients with ANCA-associated vasculitis: Case-series and literature review. Soussan M, Abisror N, Abad S, Nunes H, Terrier B, Aydin M, Pop G, Eder V, Valeyre D, Sberro-Soussan R, Guillevin L, Dhote R, Fain O, Mekinian A. Autoimmun Rev. 2014;13(2):125-31.

Anti-SSA Ro52/Ro60 antibodies testing by immunodot could help the diagnosis of Sjogren’s syndrome in the absence of anti-SSA/SSB antibodies by ELISA. Mekinian A, Nicaise-Roland P, Chollet-Martin S, Fain O, Crestani B. Rheumatology (Oxford). 2013;52(12):2223-8

Catastrophic antiphospholipid syndrome and pregnancy: an experience of 13 cases. Hanouna G, Morel N, Le Thi Huong D, Josselin L, Vauthier-Brouzes D, Saadoun D, Kettaneh A, Levesque K, Le Guern V, Goffinet F, Carbonne B, Amoura Z, Piette JC, Nizard J, Costedoat-Chalumeau N.  Rheumatology (Oxford). 2013 Sep;52(9):1635-41.

Inflammatory aortitis in giant cell arteritis. Josselin-Mahr L, El Hessen TA, Toledano C, Fardet L, Kettaneh A, Tiev K, Cabane J.  Presse Med. 2013 Feb;42(2):151-9.

Tocilizumab in refractory Takayasu arteritis: A case series and updated literature review. Abisror N, Mekinian A, Lavigne C, Vandenhende MA, Soussan M, Fain O; Club Rhumatismes et Inflammation, and SNFMI. Autoimmun Rev. 2013;12(12):1143-9.

European registry of babies born to mothers with antiphospholipid syndrome. Mekinian A, Lachassinne E, Nicaise-Roland P, Carbillon L, Motta M, Vicaut E, Boinot C, Avcin T, Letoumelin P, De Carolis S, Rovere-Querini P, Lambert M, Derenne S, Pourrat O, Stirnemann J, Chollet-Martin S, Biasini-Rebaioli C, Rovelli R, Lojacono A, Ambrozic A, Botta A, Benbara A, Pierre F, Allegri F, Nuzzo M, Hatron PY, Tincani A, Fain O, Aurousseau MH, Boffa MC. Ann Rheum Dis. 2013;72(2):217-22.